On June 25, 1943, the 100 BG flew its first combat mission for Eighth Air Force against the submarine yards at Bremen, Germany -- the beginning of the "Bloody Hundredth"’s legacy. The group inherited the "Bloody Hundredth" nickname from other bomb groups due to the amount of losses it took. Although the 100 BG’s losses were no more than any other units’ at the war’s end, the group experienced several instances where it lost a dozen or more aircraft on a single mission, whereas most units suffered losses in consistent small amounts.

http://en.wikipedia.org/wiki/100th_Air_Refueling_Wing

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